Ben Grimm / The Thing

Main Comics (616)
Ben is initially shown to have an unrequited attraction to Susan Storm, his best friend's fiancee. He apparently soon gets over this.
 * 1)  Alicia Masters  becomes his main love interest and longtime girlfriend. They broke up after he decided to remain in exile on an alien planet after the events of Secret Wars, even after his return. She apparently later fell in love with Johnny Storm, even getting engaged to him, but on their wedding day, this was revealed to be a Skrull impersonator named Lyja. The real Alicia, previously held captive, returned to her life.

AU

 * 1)  Sue Storm / Invisible Woman  - In one version of reality, Ben largely takes Reed's place in the Fantastic Four, including as Susan's husband, while Reed lives in self-imposed exile.

Fantastic Four (second cartoon)

 * 1)  Alicia Masters  is portrayed in this series, along with her relationship with Ben.

Fantastic Four (2005 film)

 * 1)  Debbie  is initially Ben's fiance. Once he becomes The Thing, however, she is unable to cope, and leaves him.
 * 2)  Alicia Masters  then meets Ben, and the two become an item.