Victor Von Doom / Doctor Doom

Main Comics (616)

 * 1)  Wanda Maximoff / Scarlett Witch  - Yeah, these two totally did it.

Alternate Universes

 * 1)  Susan Storm / Invisible Woman 

Fantastic Four (2005)
In this film, Victor has a somewhat poorly defined relationship with Susan Storm. She is his employee and Reed Richards believes through much of the film that they are in a relationship. Victor, in the first half of the film, proposes to Sue, saying "think of it as a promotion." She does not answer at first, and then, of course, the characters become The Fantastic Four and Doctor Doom. She later tells Reed "There is no me and Victor. There never was." And then, of course, he tries to kill them all.

Fantastic Four (2015)
In this film, too, it is shown that Victor has an unrequited attraction to Susan, prior to becoming enemies.